The CSI team investigates a well-orchestrated bombing at the funeral of Officer Franklin Clark.

由Gil Grissom领导的拉斯维加斯警局犯罪鉴证科夜班组的任务是深入案发现场寻找种种蛛丝马迹，并利用最先进的科技手段，把表面上没有任何联系、没有意义的线索拼凑成不可辩驳的证据，抽丝剥茧重组案情，让犯罪分子无处可逃…… 　　这套剧集展现了大量前沿尖端的高科技侦破技术：弹道学、犯罪危险因子学、法医

Under the direction of new boss D.B. Russell, the team tackles cases involving a wild shootout on a Las Vegas tram car, and the death of a deer hunter

While Ecklie fights for his life after his shooting, Russell's patience begins to wear thin as the team tries to get to his kidnapped granddaughte

Russell and Finlay must confront a serial killer case from their past while working in Seattle when a copycat killer suddenly emerges in Las Vegas.

CSI的故事背景设在赌城拉斯维加斯，以真人真事改编，讲述刑事警察局的法庭犯罪调查员如何在作案现场取得证据破案的故事。调查员的名言是“死尸会说话”，他们利用指纹、鞋印、子弹壳、血迹、毛发、纤维、尸体伤痕等微小证据，经过仔细的分析研究后，寻得破案的关键。 解开谜团的过程颇有吸引力。

Russell and Finlay must confront a serial killer case from their past while working in Seattle when a copycat killer suddenly emerges in Las Vegas.